Surface antigens and proteins useful in compositions for the diagnosis and prevention of lyme disease
AssigneeThe Administrators of the Tulane Educational Fund
InventorMario T. Philipp
Life of this patent
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Abstract
A novel isolated Borrielia burgdorferi sensu lato surface antigen is characterized by a relative molecular mass of 39.5 kDa. This antigen is expressed in vitro by spirochetes of a B. burgdorferi sensu lato strain. This antigen induces antibodies which kill spirochetes of a B. burgdorferi sensu lato strain by ADCK in vitro. Novel Borrelia cassette string protein or fragments thereof are also useful, as is the P39.5 protein in diagnosing Lyme disease and in compositions for treatment or prophylaxis thereof.
Claims6
A recombinant or synthetic protein or peptide that binds with antibodies to the causative agent of Lyme Disease in infected humans or animals, said protein or peptide selected from the group consisting of:
- (a) an amino acid sequence of SEQ ID NO:
- 2;
- (b) an amino acid sequence of SEQ ID NO:
- 14;
- (c) an amino acid sequence encoded by SEQ ID NO:
- 3;
- (d) an amino acid sequence encoded by SEQ ID NO:
- 7;
- (e) an amino acid sequence encoded by SEQ ID NO:
- 11;
- and
- (f) an amino acid sequence of a fragment of (a) through (e) of at least five amino acids in length.
Dependencies are inferred from the claim text.