Homologous 28-kilodalton immunodominant protein genes of Ehrlichia canis and uses thereof
AssigneeResearch Development Foundation
InventorsDavid H. Walker, Xue-Jie Yu, Jere W. McBride
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Abstract
The present invention is directed to the cloning, sequencing and expression of homologous immunoreactive 28-kDa protein genes, p28-1, -2, -3, -5, -6, -7, -9, from a polymorphic multiple gene family of Ehrlichia canis. Further disclosed is a multigene locus encoding all nine homologous 28-kDa protein genes of Ehrlichia canis. Recombinant Ehrlichia canis 28-kDa proteins react with convalescent phase antiserum from an E. canis-infected dog, and may be useful in the development of vaccines and serodiagnostics that are particularly effective for disease prevention and serodiagnosis.
Claims2
A method of inhibiting Ehrlichia canis infection in a subject comprising the steps of:
- identifying a subject prior to exposure or suspected of being exposed to or infected with Ehrlichia canis;
- and
- administering a composition comprising a 28-kDa antigen of Ehrlichia canis in an amount effective to inhibit Ehrlichia canis infection, wherein said 28-kDa antigen comprises amino acid sequence of SEQ ID No. 2.
Dependencies are inferred from the claim text.