Proteasome regulation of NF-KB activity
AssigneePresident and Fellows of Harvard College
InventorsVito J. Palombella, Alfred L. Goldberg, Thomas P. Maniatis, Oliver Rando
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Abstract
Disclosed herein is a method for regulating the activity of NF-κB in an animal comprising contacting cells of the animal with certain proteasome inhibitors.
Claims3
A method for treating a human with an inflammatory condition caused by NF-κB activity, said method comprising administering to the human a selective inhibitor of proteasome function or ubiquitin conjugation in an amount sufficient to reduce NF-κB activity.
A method for treating a human having an inflammatory condition comprising determining whether the human has elevated IL-6 or TNF-α levels and administering to the human a selective inhibitor of proteasome function or ubiquitin conjugation at a level sufficient to reduce NF-κB activity, whereby IL-6 or TNF-α levels are reduced.
Dependencies are inferred from the claim text.