Treatment of intracellular infection
AssigneeHealth Protection Agency
InventorsVladimir Artymovich Pasechnik, Allen Douglas Glen Roberts, Richard James Sharp
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Abstract
An agent for combating an intracellular microbial infection comprises a phage component and, associated therewith, a targeting moiety which directs the agent to a target cell and initiates delivery of the phage into the target cell. Once inside the target cell, the phage causes lysis of a microorganism residing within the target cell. A mycobacteriophage is combined with a targeting moiety of transferrin. Compositions comprising the agent, methods of preparing said agent, and use of said agent for combating intracellular infections are also provided.
Claims10
A mycobacteriophage that includes a ligand associated with the mycobacteriophage, wherein the ligand is a transferrin molecule, or a fragment thereof that binds to a transferrin receptor on a macrophage or monocyte, and wherein following binding of the ligand to the macrophage or monocyte the mycobacteriophage enters the macrophage or monocyte and effects lysis of a microorganism residing within the macrophage or monocyte.
A mycobacteriophage that includes a ligand associated with the mycobacteriophage, wherein the ligand is a transferrin molecule or a fragment thereof that binds to a transferrin receptor on the surface of a macrophage or monocyte said ligand being exogenous with respect to the mycobacteriophage, and wherein following binding of the ligand to the macrophage or monocyte the mycobacteriophage enters the macrophage or monocyte and effects lysis of a microorganism residing within the macrophage or monocyte.
Dependencies are inferred from the claim text.