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US 6,660,257 B1Granted
Circular permuteins of flt3 ligand
AssigneePharmacia Corporation
InventorsCharles A. McWherter, Yiqing Feng, John P. Mc Kearn, Nicholas R. Staten, Philip R. Streeter, Susan L. Woulfe, Nancy I. Minster, John C. Minnerly
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Abstract
Disclosed are novel flt-3 receptor agonist proteins, DNAs which encode the flt-3 receptor agonist proteins, methods of making the flt-3 receptor agonist proteins and methods of using the flt-3 receptor agonist proteins.
Claims11
A human flt-3 receptor agonist polypeptide, comprising a modified flt-3 ligand amino acid sequence selected from the group consisting of:
- (a) the sequence of SEQ ID NO:
- 144;
- and
- (b) a polypeptide comprising residues 1-132 of SEQ ID NO:
- 144;
- wherein said modification comprises the linear rearrangement of the sequences of (a) or (b);
- wherein the N-terminus is joined to the C-terminus directly or through a linker capable of joining the N-terminus to the C-terminus and new C- and N-termini are created between the amino acid residue pairs of SEQ ID NO:
- 144 selected from the group consisting of:
- 28-29, 29-30, 30-31, 31-32, 32-33, 34-35, 36-37, 37-38, 38-39, 40-41, 41-42, 42-43, 64-65, 65-66, 66-67, 86-87, 88-89, 89-90, 90-91, 91-92, 92-93, 93-94, 94-95, 95-96, 96-97, 97-98, 98-99, 99-100, 100-101, 101-102, and 102-103;
- and
- wherein optionally said flt-3 receptor agonist polypeptide is immediately preceded by (methionine−1), (alanine−1) or (methionine−2, alanine−1).
8 more elements
Dependencies are inferred from the claim text.