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US 6,660,197 B1Granted
Method for producing an elongated drug formation
AssigneeNovo Nordisk A/S
InventorsThomas Buch-Rasmussen, Søren Aasmul, James M. Flink, Philip Hansen, Claus Juul-Mortensen, Jens-Ulrik Poulsen
Life of this patent
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Abstract
The present invention relates to a method and a system for producing an elongated drug formulation being suitable for being injected through the skin of a patient with-out the use of a needle or a cannula. The drug formulation is produced by compressing a drug granulate in cavity of a system comprising a roller and a surface, wherein the roller roles over the surface thereby comprising the granulate to the formulation.
Claims36
A method for producing an elongated drug formulation comprising
- arranging a first roller adjacent a surface, whereby a cavity is defined between the first roller and the surface, the shape of the drug formulation being defined by the cavity,
- feeding a gap between the first roller and the surface with drug granulate,
- rolling the roller against the surface whereby a pressure is applied to the drug granulate and the drug formulation is formed in the cavity,
- disengaging the first roller from the surface, and
- releasing the compressed drug formulation from the pocket cavity;
- wherein pressure applied to the drug granulate is in the range of 25-5000 kg/cm2 and the density of the uncompressed drug, granulate is in the range of 0.1-1.6 g/cm3.
3 more elements
A method for producing an elongated drug formulation comprising:
- arranging a first roller adjacent a surface, whereby a cavity is defined between the first roller and the surface, the shape of the drub formulation beings defined by the cavity,
- feeding a gap between the first roller and the surface with drug granulate,
- rolling the roller against the surface whereby a pressure is applied to the drug granulate and the drug formulation is formed in the cavity,
- disengaging the first roller from the surface, and
- releasing the compressed drug formulation from the pocket cavity, wherein the elongated drug formulation has a substantially circular cross section, the diameter of said formulation being in the range of 0.2-1.0 mm.
2 more elements
A method for producing an elongated drug formulation comprising
- arranging a first roller adjacent a surface, whereby a cavity is defined between the first roller and the surface, the shape of the drug formulation being defined by the cavity,
- feeding a gap between the first roller and the surface with drug granulate,
- rolling the roller against the surface whereby a pressure is applied to the drug granulate and the drug formulation is formed in the cavity,
- disengaging the first roller from the surface, and
- releasing the compressed drug formulation from the pocket cavity, wherein the ratio of the average diameter of the drug granulate to the diameter of the cross section of the drug formulation is at the most 1:2.
2 more elements
A method for producing an elongated drug formulation comprising
- arranging a first roller adjacent a surface, whereby a cavity is defined between the first roller and the surface, the shape of the drug formulation being defined by the cavity,
- feeding a gap between the first roller and the surface with drug granulate,
- rolling the roller against the surface whereby a pressure is applied to the drug granulate and the drug formulation is formed in the cavity,
- disengaging the first roller from the surface, and
- releasing the compressed drug formulation from the pocket cavity, wherein the average diameter of the drug granulate is in the range of 10-250 micrometers.
2 more elements
A method for producing an elongated drug formulation comprising
- arranging a first roller adjacent a surface, whereby a cavity is defined between the first roller and the surface, the shape of the drug formulation being defined by the cavity,
- feeding a gap between the first roller and the surface with drug granulate,
- rolling the roller against the surface whereby a pressure is applied to the drug granulate and the drug formulation is formed in the cavity,
- disengaging the first roller from the surface, and
- releasing the compressed drug formulation from the pocket cavity, wherein the density of the compressed drug formulation is at least 2 times the density of the uncompressed drug granulate.
2 more elements
A method for producing an elongated drug formulation comprising
- arranging a first roller adjacent a surface, whereby a cavity is defined between the first roller and the surface, the shape of the drug formulation being defined by the cavity,
- feeding a gap between the first roller and the surface with drug granulate,
- rolling the roller against the surface whereby a pressure is applied to the drug granulate and the drug formulation is formed in the cavity,
- disengaging the first roller from the surface, and
- releasing the compressed drug formulation from the pocket cavity, wherein the ratio of the length of the elongated drug formulation to the diameter of the elongated drug formulation is between 100.1 and 3:1.
2 more elements
A method for producing an elongated drug formulation comprising
- arranging a first roller adjacent a surface, whereby a cavity is defined between the first roller and the surface, the shape of the drug formulation being defined by the cavity,
- feeding a rap between the first roller and the surface with drug granulate, rolling the roller against the surface whereby a pressure is applied to the drug granulate and the drug formulation is formed in the cavity, disengaging the first roller from the surface, and
- releasing the compressed drug formulation from the pocket cavity, wherein the length of the elongated drug formulation is in the range of 1-20 mm.
A method for producing an elongated drug formulation comprising
- arranging a first roller adjacent a surface, whereby a cavity is defined between the first roller and the surface, the shape of the drug formulation being defined by the cavity,
- feeding a gap between the first roller and the surface with drug granulate,
- rolling the roller against the surface whereby a pressure is applied to the drug granulate and the drug formulation is formed in the cavity,
- disengaging the first roller from the surface, and
- releasing the compressed drug formulation from the pocket cavity, wherein the elongated drug formulation comprises a pointed end.
2 more elements
A method for producing an elongated drug formulation comprising
- arranging a first roller adjacent a surface, whereby a cavity is defined between the first roller and the surface, the shape of the drug formulation being defined by the cavity,
- feeding a gap between the first roller and the surface with drug granulate,
- rolling the roller against the surface whereby a pressure is applied to the drug granulate and the drug formulation is formed in the cavity,
- disengaging the first roller from the surface, and
- releasing the compressed drug formulation from the pocket cavity, wherein the pointed end tapers in an angle less than 90 degrees.
2 more elements
A method for producing an elongated drug formulation comprising
- arranging a first roller adjacent a surface, whereby a cavity is defined between the first roller and the surface, the shape of the drug formulation being defined by the cavity,
- feeding a gap between the first roller and the surface with drug granulate,
- rolling the roller against the surface whereby a pressure is applied to the drug granulate and the drug formulation is formed in the cavity,
- disengaging the first roller from the surface, and
- releasing the compressed drug formulation from the pocket,
- wherein the cavity is a pocket cavity arranged in the first roller, wherein the inner shape of the sub-cavity is substantially identical to the inner shape of the pocket cavity.
3 more elements
A method for producing an elongated drug formulation comprising
- arranging a first roller adjacent a surface, whereby a cavity is defined between the first roller and the surface, the shape of the drug formulation being defined by the cavity,
- feeding a gap between the first roller and the surface with drug granulate,
- rolling the roller against the surface whereby a pressure is applied to the drug granulate and the drug formulation is formed in the cavity,
- disengaging the first roller from the surface, and
- releasing the compressed drug formulation from the pocket, wherein the cavity is a pocket cavity arranged in the first roller, wherein the inner shape of the pocket cavity defines more than half of the outer shape of the drug formulation.
2 more elements
A method for producing an elongated drug formulation comprising
- arranging a first roller adjacent a surface, whereby a cavity is defined between the first roller and the surface, the shape of the drug formulation being defined by the cavity,
- feeding a gap between the first roller and the surface with drug granulate,
- rolling the roller against the surface whereby a pressure is applied to the drug granulate and the drug formulation is formed in the cavity,
- disengaging the first roller from the surface, and releasing the compressed drug formulation from the pocket cavity, wherein the cavity is a pocket cavity arranged in the first roller, and wherein the surface is part of a conveying belt.
1 more element
A method for producing an elongated drug formulation comprising
- arranging a first roller adjacent a surface, whereby a cavity is defined between the first roller and the surface, the shape of the drug formulation being defined by the cavity,
- feeding a gap between the first roller and the surface with drug granulate,
- rolling the roller against the surface whereby a pressure is applied to the drug granulate and the drug formulation is formed in the cavity,
- disengaging the first roller from the surface, and releasing the compressed drug formulation from the pocket cavity, wherein a pressure is applied to the drug granulate before feeding.
1 more element
A method for producing an elongated drug formulation comprising
- arranging a first roller adjacent a surface, whereby a cavity is defined between the first roller and the surface, the shape of the drug formulation being defined by the cavity,
- feeding a cap between the first roller and the surface with drug granulate,
- rolling the roller against the surface whereby a pressure is applied to the drug granulate and the drug formulation is formed in the cavity,
- disengaging the first roller from the surface, and
- releasing the compressed drug formulation from the pocket cavity, wherein a pressure is applied to the drug granulate during feeding.
2 more elements
A method for producing an elongated drug formulation comprising
- arranging a first roller adjacent a surface, whereby a cavity is defined between the first roller and the surface, the shape of the drug formulation being defined by the cavity,
- feeding a gap between the first roller and the surface with drug granulate,
- rolling the roller against the surface whereby a pressure is applied to the drug granulate and the drug formulation is formed in the cavity,
- disengaging the first roller from the surface, and
- releasing the compressed drug formulation from the pocket cavity, wherein the first roller is rolled continuously against the surface.
2 more elements
A method for producing an elongated drug formulation comprising
- arranging a first roller adjacent a surface, whereby a cavity is defined between the first roller and the surface, the shape of the drug formulation being defined by the cavity,
- feeding a gap between the first roller and the surface with drug granulate,
- rolling the roller against the surface whereby a pressure is applied to the drug granulate and the drug formulation is formed in the cavity,
- disengaging the first roller from the surface, and
- releasing the compressed drug formulation from the pocket cavity, wherein the first roller is rolled stepwise, whereby a feeding step is followed by a rolling/compression step.
2 more elements
A method for producing an elongated drug formulation comprising
- arranging a first roller adjacent a surface, whereby a cavity is defined between the first roller and the surface, the shape of the drug formulation being defined by the cavity,
- feeding a gap between the first roller and the surface with drug granulate,
- rolling the roller against the surface whereby a pressure is applied to the drug granulate and the drug formulation is formed in the cavity,
- disengaging the first roller from the surface, and
- releasing the compressed drug formulation from the pocket cavity, wherein the compressed drug formulation is released by means of vacuum suction.
2 more elements
A method for producing an elongated drug formulation comprising
- arranging a first roller adjacent a surface, whereby a cavity is defined between the first roller and the surface, the shape of the drug formulation being defined by the cavity,
- feeding a gap between the first roller and the surface with drug granulate,
- rolling the roller against the surface whereby a pressure is applied to the drug granulate and the drug formulation is formed in the cavity,
- disengaging the first roller from the surface, and
- releasing the compressed drug formulation from the pocket cavity, wherein an expeller is arranged in the pocket cavity for releasing the compressed drug formulation from the cavity.
2 more elements
A method for producing an elongated drug formulation comprising
- arranging a first roller adjacent a surface, whereby a cavity is defined between the first roller and the surface, the shape of the drug formulation being defined by the cavity,
- feeding a gap between the first roller and the surface with drug granulate,
- rolling the roller against the surface whereby a pressure is applied to the drug granulate and the drug formulation is formed in the cavity,
- disengaging the first roller from the surface, and
- releasing the compressed drug formulation from the pocket cavity, wherein the compressed drug formulation is released by means of a continuous band lining each pocket cavity or sub-cavity.
2 more elements
A method for producing an elongated drug formulation comprising
- arranging a first roller adjacent a surface, whereby a cavity is defined between the first roller and the surface the shape of the drug formulation being defined by the cavity,
- feeding a gap between the first roller and the surface with drug granulate,
- rolling the roller against the surface whereby a pressure is applied to the drug granulate and the drug formulation is formed in the cavity,
- disengaging the first roller from the surface, and
- releasing the compressed drug formulation from the pocket cavity, wherein the first roller comprises at least two pocket cavities, and wherein the shortest distance between the center of two adjacent cavities corresponds to at least the diameter of the drug formulation.
2 more elements
A method for producing an elongated drug formulation comprising
- arranging a first roller adjacent a surface, whereby a cavity is defined between the first roller and the surface, the shape of the drug formulation being defined by the cavity,
- feeding a gap between the first roller and the surface with drug granulate,
- rolling the roller against the surface whereby a pressure is applied to the drug granulate and the drug formulation is formed in the cavity,
- disengaging the first roller from the surface, and
- releasing the compressed drug formulation from the pocket cavity, wherein the diameter of the first roller is at least 1 cm.
2 more elements
A method for producing an elongated drug formulation comprising
- arranging a first roller adjacent a surface, whereby a cavity is defined between the first roller and the surface, the shape of the drug formulation being defined by the cavity,
- feeding a gap between the first roller and the surface with drug granulate,
- rolling the roller against the surface whereby a pressure is applied to the drug granulate and the drug formulation is formed in the cavity,
- disengaging the first roller from the surface, and
- releasing the compressed drug formulation from the pocket cavity, wherein the cavity is heated to above room temperature during production of a drug formulation.
2 more elements
Dependencies are inferred from the claim text.