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US 6,659,107 B2Granted
Method to prevent xenograft transplant rejection
AssigneesQLT Inc., The University of British Columbia
InventorsModestus O. K. Obochi, Philippe Maria Clotaire Margaron, Christopher Richard Honey, Stephen Yip, Julia G. Levy
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Abstract
Donor material from a xenogeneic source is modified to enhance its survival time in a recipient by treating the donor material using low-dose photodynamic therapy (PDT). The donor material, such as an organ or cell suspension, is treated with a photosensitizer and irradiated in a low-dose protocol before transplantation into a xenogeneic recipient.
Claims16
A method to enhance the survival of xenogeneic donor material, which method comprises
- contacting donor material comprising living cells with a photosensitizer at a concentration and for a time effective to photosensitize said material;
- irradiating said photosensitized material with radiation at a wavelength absorbed by the photosensitizer for a time and at an intensity to provide sufficient total energy to enhance the survival of said material in a recipient while maintaining viability of said living cells,
- thus modifying said donor material so as to enhance its survival time in a xenogeneic recipient,
- wherein the concentration of the photosensitizer, the intensity of the radiation, and the total energy provided are adjusted to provide said donor material with low-dose photodynamic therapy.
1 more element
Dependencies are inferred from the claim text.