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US 6,656,968 B1Granted
(Z)-styryl acetoxyphenyl sulfides as cyclooxygenase inhibitors
AssigneeTemple University of the Commonwealth System of Higher Education
InventorsE. Premkumar Reddy, M. V. Ramana Reddy
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Abstract
Compounds of the formula are provided wherein R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen, halogen, hydroxyl, C1-C8 alkyl, C1-C6 alkoxy, nitro, cyano, acetoxy, amino, carboxy, sulfamyl, lower acylsulfamyl and trifluoromethyl. The compounds are inhibitors of cyclooxygenase-2 activity, useful for treating inflammation and cyclooxygenase-mediated disorders.
Claims22
A compound of the formula:
- wherein R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen, halogen, hydroxyl, C1-C8 alkyl, C1-C6 alkoxy, nitro, cyano, acetoxy, amino, carboxy, sulfamyl, lower acylsulfamyl and trifluoromethyl;
- or a pharmaceutically acceptable salt thereof.
A compound of the formula:
- wherein R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen, halogen, hydroxyl, C1-C8 alkyl, C1-C6 alkoxy, nitro, cyano, acetoxy, amino, carboxy, sulfamyl, lower acylsulfamyl and trifluoromethyl.
A method for producing a compound of formula I
- wherein R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen, halogen, hydroxyl, C1-C8 alkyl, C1-C6 alkoxy, nitro, cyano, acetoxy, amino, carboxy, sulfamyl, lower acylsulfamyl and trifluoromethyl, comprising reacting a compound according to formula IV
- wherein R1, R2, R3 and R4 are so defined, with acetic anhydride, and isolating a compound according to formula I.
A compound of the formula:
- wherein
- x is from about 10 to about 150;
- and
- R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen, halogen, hydroxyl, C1-C8 alkyl, C1-C6 alkoxy, nitro, cyano, acetoxy amino, carboxy, sulfamyl, lower acylsulfamyl and trifluoromethyl.
1 more element
Dependencies are inferred from the claim text.