Human choline acetyltransferase
AssigneeHuman Genome Sciences, Inc.
InventorsPeter L. Huson, Wei Wu He, Craig A. Rosen, Jeannine D. Gocayne
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Abstract
Human choline acetyltransferase polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of cognitive and neurological deficiencies or mental disturbances such as degenerative nervous system disorders, for example, Alzheimer's Disease, ALS and other cholinergic defects, and antagonists for treating Parkinson's Disease and other disorders relating to an over-expression of acetylcholine. Also disclosed are diagnostic methods for detecting a mutation in the human Choline Acetyltransferase nucleic acid sequence.
Claims32
An isolated protein comprising an amino acid sequence 90% or more identical to the amino acid sequence of residues 1-677 of SEQ ID NO:2, wherein said protein has choline acetyltransferase activity.
An isolated protein comprising an amino acid sequence 90% or more identical to the amino acid sequence of the polypeptide encoded by the cDNA in ATCC Deposit No. 75856, wherein said protein has choline acetyltransferase activity.
An isolated protein comprising at least 30 contiguous amino acid residues of SEQ ID NO:2, wherein said protein has choline acetyltransierase activity.
An isolated protein comprising at least 30 contiguous amino acid residues of the polypeptide encoded by the cDNA in ATCC Deposit No. 75856, wherein said protein has choline acetyltransferase activity.
Dependencies are inferred from the claim text.