Targeted integration into chromosomes using retroviral vectors
AssigneeInstitut Fur Virologie
InventorsWalter H. Günzburg, Brian Salmons, Sabine Goller, Dieter Klein
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Abstract
The present invention relates to a retroviral vector encoding heterologous genes particularly for gene therapy of genetic defects or viral infections.
Claims5
A retroviral vector comprising one or more heterologous nucleic acid sequence(s) as well as at least one sequence allowing site-specific integration of said heterologous sequence(s) into a non-coding region of a genome, wherein the sequence allowing site-specific integration is an Inverted Terminal Repeat (ITR) sequence of Adeno-associated virus (AAV), and wherein the sequence(s) allowing site specific integration is inserted at the U3 region(s) and/or the U5 region(s) of the retroviral Long Terminal Repeat (LTR).
Dependencies are inferred from the claim text.