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US 6,656,717 B1Granted
Cyclic AMP phosphodiesterase isoforms and methods of use
AssigneeMemory Pharmaceuticals Corporation
InventorsXiaonan Xin, Axel Unterbeck, Yinghe Hu
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AssigneeMemory Pharmaceuticals Corporation
InventorsXiaonan Xin, Axel Unterbeck, Yinghe Hu
Estimating the term…
Human and rat cAMP phosphodiesterase isoforms (denoted PDE4Ds), as well as the DNA (RNA) encoding such polypeptides, are disclosed. Also disclosed are methods for utilizing such polypeptides in diagnostic assays for identifying mutations in nucleic acid sequences encoding the polypeptides of the present invention, for detecting altered levels of the polypeptide of the present invention as a means of detecting diseases and methods of screening potential modulators, especially inhibitors, of the novel PDE4Ds (denoted PDE4D6) disclosed herein as a means of increasing cyclic AMP in neurons and thus treating neurological problems, such as long term memory loss, if not preventing such maladies entirely. Transgenic animals expressing polypeptides disclosed herein are also described.
An isolated polypeptide comprising an amino acid sequence that is at least 90% identical to SEQ ID NO:
An isolated polypeptide comprising an amino acid sequence that is at least 90% identical to SEQ ID NO:
An isolated polypeptide comprising an amino acid sequence having SEQ ID NO:2.
An isolated polypeptide comprising an amino acid sequence having SEQ ID NO:4.
An isolated 15-mer peptide containing at least 12 contiguous amino acids residues of SEQ ID NO:
Dependencies are inferred from the claim text.