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AssigneeNorthwest Hospital
InventorsEric H. Holmes, Anne L. Sherwood
Estimating the term…
A rat ganglioside GM1-specific α1→2fucosyltransferase is disclosed. Nucleotide sequences of a rat ganglioside GM1-specific α1→2fucosyltransferase, amino acid sequences of its encoded protein (including peptide or polypeptide), and derivatives thereof are described. Also described are fragments (and derivatives and analogs thereof) which comprise a domain of rat ganglioside GM1-specific α1→2fucosyltransferase with catalytic activity. Methods of production of rat ganglioside GM1-specific α1→2fucosyltransferase and derivatives and analogs thereof (e.g. by recombinant means) are provided. Methods of inhibiting the function of rat ganglioside GM1-specific α1→2fucosyltransferase (e.g. by means of antisense RNA) are provided. Methods of commercial scale use of the rat ganglioside GM1-specific α1→2fucosyltransferase in the production of fucosyl-saccharide compositions are described. Applications of these compositions, e.g. as additives for human nutritive compositions or immunotherapeutics for cancer, are disclosed.
An isolated protein comprising an amino acid sequence as depicted in FIG. 5 (SEQ ID NO:8).
An isolated protein comprising an amino acid sequence as depicted in FIG. 3A (SEQ ID NO:10).
An isolated protein consisting of an amino acid sequence as depicted in FIG. 5 (SEQ ID NO:8).
An isolated protein consisting of an amino acid sequence as depicted in FIG. 3A (SEQ ID NO:10).
An isolated protein, the amino acid sequence of which consists of a catalytic domain defined by amino acids numbers 28-380 as depicted in FIG. 5 (SEQ ID NO:8) or amino acids numbers 1-353 as depicted in FIG. 3A (SEQ ID NO:10).
Dependencies are inferred from the claim text.