Fermentative preparation process for and crystal forms of cytostatics
AssigneeNovartis AG
InventorsHans Hofmann, Marion Mahnke, Klaus Memmert, Frank Petersen, Thomas Schupp, Ernst Küsters, Michael Mutz
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Abstract
The invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new strain obtained by mutagenesis for the production of epothilones, as well as aspects related thereto. New crystal forms of epothilone B are also described.
Claims6
An isolated UV mutagenesis strain of Sorangium cellulosum DSM 6773, which under otherwise identical conditions, produces more epothilones than Sorangium cellulosum DSM 6773.
An isolated strain of Sorangium cellulosum selected from the strains DSM 11999 and DSM 12539.
A fermentation process of 3 wherein the epothilone is epothilone B.
A fermentation process of 4 wherein the epothilone is epothilone B.
Dependencies are inferred from the claim text.