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US 6,656,707 B2Granted
C3b/C4b complement receptor-like molecules and uses thereof
AssigneeAmgen Inc.
InventorsAndrew A. Welcher, Gary S. Elliott
Life of this patent
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Abstract
Novel C3b/C4b CR-like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, selective binding agents, and methods for producing C3b/C4b CR-like polypeptides. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with C3b/C4b CR-like polypeptides.
Claims19
An isolated nucleic acid comprising a nucleotide sequence selected from the group consisting of:
- (a) a nucleotide sequence set forth in SEQ ID NO:
- 1;
- (b) a nucleotide sequence encoding a polypeptide comprising an amino acid sequence as set forth in SEQ ID NO:
- 2;
- and
- (c) a nucleotide sequence fully complementary to (a) or (b).
3 more elements
An isolated nucleic acid comprising a nucleotide sequence selected from the group consisting of:
- (a) a nucleotide sequence encoding the polypeptide set forth in SEQ ID NO:
- 2;
- (b) a fragment of(a) wherein from 1 to 100 carboxy terminal codons have been deleted;
- (c) a fragment of (a) or (b) wherein from 1 to 100 amino terminal codons have been deleted;
- (d) a nucleotide sequence which hybridizes under stringent conditions to the full complement of any of (a)-(c) over the entire length of the sequence of (a)-(c) said stringent conditions comprising a final wash at 65° C. in 0.1×SSC and 0.1% SDS, wherein the nucleotide sequence encodes a polypeptide which has C3b/C4b complement receptor-like activity of the polypeptide set forth in SEQ ID NO:
- 2;
- and
- (e) a nucleotide sequence complementary to any of (a)-(d).
5 more elements
Dependencies are inferred from the claim text.