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US 6,656,688 B1Granted
Antisense modulation of NF-kappa-B p65 subunit expression
AssigneeIsis Pharmaceuticals, Inc.
InventorsC. Frank Bennett, Brett P. Monia, Lex M. Cowsert
Life of this patent
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Abstract
Antisense compounds, compositions and methods are provided for modulating the expression of NF-kappa-B p65 subunit. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding NF-kappa-B p65 subunit. Methods of using these compounds for modulation of NF-kappa-B p65 subunit expression and for treatment of diseases associated with expression of NF-kappa-B p65 subunit are provided.
Claims12
An antisense compound from 8 to 30 nucleotides in length targeted to a nucleic acid molecule encoding human NF-kappa-B p65 subunit of SEQ ID NO:
- 1, wherein said antisense compound is an antisense oligonucleotide and has a sequence comprising SEQ ID NO:
- 12, 23, 25, 26, 37, 40, 44, or 45, and wherein said antisense compound inhibits the expression of human NF-kappa-B p65 subunit.
Dependencies are inferred from the claim text.