Laser scanning cytology with digital image capture
AssigneeBoard of Regents, The University of Texas System
InventorsJames M. Reuben, Terry L. McCutcheon
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Abstract
The methods described herein are directed to subjecting a biological cell sample with multiple cell characteristics, such as DNA ploidy, immunophenotype or cellular morphology, to a laser-based interrogation with the penultimate step being creation of a digital image of the cell sample. This digital image greatly enhances the comprehensive analysis of the sample and facilitates diagnosis of the cell characteristics upon its creation in a digital format, which may also be captured in a tangible format such as a hard copy, either of which are suitable for transmission to a diagnostician, health care provider or patient.
Claims45
A method for recording cell sample data comprising:
- (a) providing a sample containing a cell;
- (b) subjecting said sample to a laser-based interrogation;
- and
- (c) directly capturing a digital image of one or more cell characteristics.
A method of diagnosing cancer comprising:
- (a) providing a sample containing a cell;
- (b) subjecting said sample to a laser-based interrogation;
- (c) directly capturing a digital image of one or more cell characteristics;
- and
- (d) identifying aneuploidy based on said one or more cell characteristics.
A method for creating a cell data record comprising:
- (a) subjecting a cell to laser interrogation;
- and
- (b) directly recording in a tangible medium one or more cell characteristics in a digital format.
A method for recording cell sample data comprising:
- (a) providing a sample containing a cell;
- (b) subjecting said sample to a laser-based interrogation;
- and
- (c) capturing by digital camera a digital image of one or more cell characteristics.
A method of diagnosing cancer comprising:
- (a) providing a sample containing a cell;
- (b) subjecting said sample to a laser-based interrogation;
- (c) capturing by digital camera a digital image of one or more cell characteristics;
- and
- (d) identifying aneuploidy based on said one or more cell characteristics.
A method for creating a cell data record comprising:
- (a) subjecting a cell to laser interrogation;
- and
- (b) recording by a digital camera one or more cell characteristics in a digital format.
Dependencies are inferred from the claim text.