Therapeutic, diagnostic, or hydrophilic coating for an intracorporeal medical device

A method of providing a therapeutic, diagnostic or hydrophilic coating on an intracorporeal medical device, comprising:

• a) applying to the medical device a solution having a grafting component and a binding component, wherein the grafting component is selected from the group consisting of vinyl, acrylate and allyl compounds, and the binding component has at least a first functional group selected from the group consisting of aziridine, carbodiimide, aldehyde, isocyanate, succinimide, maleimide, oxirane, and carboxyl derivatized with one of carbodiimide, tresyl, or succinimide;
• b) polymerizing the grafting component in the presence of the binding component, so that the grafting component polymerizes on the medical device, and bonding the grafting component to the binding component, to form a base coat on the device;
• and
• c) applying to the base coat a solution of a therapeutic, diagnostic or hydrophilic agent having a functional group which covalently bonds to the binding component, to form the therapeutic, diagnostic or hydrophilic coating on the medical device.

A method of providing a therapeutic, diagnostic or hydrophilic coating on an intracorporeal medical device, comprising:

• a) applying to the medical device a solution having a grafting component and a binding component, wherein the grafting component is selected from the group consisting of vinyl, acrylate and allyl compounds, and the binding component has at least a first functional group selected from the group consisting of aziridine, carbodiimide, aldehyde, isocyanate, succinimide, maleimide, oxirane, and carboxyl derivatized with one of carbodiimide, tresyl, or succinimide;
• b) polymerizing the grafting component in the presence of the binding component, so that the grafting component polymerizes on the medical device, and bonding the graft component to the binding component, to form a base coat on the device;
• c) applying to the base coat a solution comprising a linking agent having a functional group which covalently bonds to the binding component;
• and
• d) exposing the linking agent to a solution of a therapeutic, diagnostic or hydrophilic agent, so that a complex comprising the linking agent and the therapeutic, diagnostic or hydrophilic agent is formed, to form the therapeutic, diagnostic or hydrophilic coating on the medical device.