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US 6,656,508 B2Granted
Sustained-release alginate gels
AssigneeAmgen Inc.
InventorsMerrill Seymour Goldenberg, Alice C. Beekman
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Abstract
The present invention relates to sustained-release formulations using alginate gel beads and methods thereof.
Claims18
A sustained-release gel bead composition for delivery by injection, comprising:
- a) a hydrophilic polymer;
- b) a biologically active agent;
- and
- c) at least two precipitating agents;
- wherein at least one of the precipitating agents is zinc and co-precipitates the biologically active agent, and further wherein the beads are formed in a mixture having an acidic pH.
2 more elements
Dependencies are inferred from the claim text.