Method for forming an aqueous flocculated suspension
AssigneeAlpharma USPD Inc.
InventorsSubhas Kundu, Vivek Desai, Andrea Cameron
Life of this patent
Estimating the term…
Abstract
An aqueous pharmaceutical composition suitable for oral delivery has an insoluble active substance and a wetting agent in liquid suspension. The composition contains floccules of the active ingredient. The formulation has an excellent shelf-life in which caking and sedimentation are inhibited. The composition may be resuspended upon light to moderate shaking.
Claims24
A method for forming an aqueous flocculated suspension containing 40 mg/ml micronized megestrol acetate together with a wetting agent to form a stable, resuspendable flocculated suspension of megestrol acetate, comprising mixing the wetting agent with micronized megestrol acetate in an amount such that about 90% of the floccules of megestrol acetate in the suspension have a diameter of less than 12 to 50 microns, and wherein the flocculated suspension does not simultaneously contain polysorbate and polyethylene glycol.
A method for forming an aqueous flocculated suspension containing 40 mg/ml micronized megestrol acetate together with a wetting agent to form a stable, resuspendable flocculated suspension of megestrol acetate, comprising mixing the wetting agent with micronized megestrol acetate in an amount such that about 50% of the floccules of megestrol acetate in the suspension have a diameter of less than 17 microns, and wherein die flocculated suspension does not simultaneously contain polysorbate and polyethylene glycol.
A method for forming an aqueous flocculated suspension containing 40 mg/ml micronized megestrol acetate together with a wetting agent to form a stable, resuspendable flocculated suspension of megestrol acetate, comprising mixing the wetting agent with micronized megestrol acetate in an amount such that about 10% of the floccules of megestrol acetate in the suspension have a diameter of less than 7 microns, and wherein the flocculated suspension does not simultaneously contain polysorbate and polyethylene glycol.
Dependencies are inferred from the claim text.