Pharmaceutical tablet comprising an NSAID and misoprostol

A process of making a pharmaceutical composition comprising the steps of making a core tablet comprising an NSAID, and applying around the core a film coating comprising a polymer and misoprostol by dissolving the polymer and misoprostol in solvent, spraying the solution on said core, evaporating the solvent and subsequently applying an inert coating to said film coating, wherein the weight ratio of the solvent based thin film coating to the coated tablet is selected from the group of ratios comprising less than about 5%, less than about 10%, and less than about 50%.

A process of making a pharmaceutical composition comprising the steps of making a core tablet comprising an NSAID, applying an enteric coating around the core, and applying an overcoating around the enteric coating comprising a polymer and misoprostol by dissolving the polymer and misoprostol in solvent, spraying the solution, and evaporating the solvent, wherein the weight ratio of the solvent based thin film coating to the coated tablet is selected from the group of ratios comprising less than about 5%, less than about 10%, and less than about 50%.

A pharmaceutical composition in the form of a tablet comprising a core and a thin solvent based film coating applied over the core, wherein the core comprises an NSAID and the film coating comprises a polymer and misoprostol, and further comprising an inert coating applied to the film coating comprising the polymer and misoprostol, wherein the weight ratio of the solvent based thin film coating to the coated tablet is selected from the group of ratios comprising less than about 5%, less than about 10%, and less than about 50%.

A pharmaceutical composition in the form of a tablet comprising a core and a thin solvent based film coating applied over the core, wherein the core comprises an NSAID and the film coating comprises a polymer and misoprostol, wherein the weight ratio of the solvent based thin film coating to the coated tablet is selected from the group of ratios comprising less than about 5%, less than about 10%, and less than about 50%.

A process of making a pharmaceutical composition comprising the steps of making a core tablet comprising an NSAID, applying an enteric coating around the core, and applying an overcoating around the enteric coating comprising a polymer and misoprostol by dissolving the polymer and misoprostol in solvent, spraying the solution, and evaporating the solvent, wherein the weight ratio of the solvent based thin film coating to the coated tablet is selected from the group of ratios comprising less than about 1:20 and, less than about 1:10 thereby achieving a significantly smaller tablet to facilitate easier swallowing wherein the solvent comprises a chlorinated hydrocarbon and an alcohol.

A process of making a pharmaceutical composition comprising the steps of making a core tablet comprising an NSAID, applying an enteric coating around the core, and applying an overcoating around the enteric coating comprising a polymer and misoprostol by dissolving the polymer and misoprostol in solvent, spraying the solution, and evaporating the solvent, wherein the weight ratio of the solvent based thin film coating to the coated tablet is selected from the group of ratios comprising less than about 1:20 and, less than about 1:10 thereby achieving a significantly smaller tablet to facilitate easier swallowing wherein an inert coating is applied subsequently to said film coating.