Back to results
US 6,656,499 B1Granted
Composition for transdermal and dermal administration of interferon-α
AssigneePharmaDerm Laboratories Ltd.
InventorsMarianna Foldvari, Sam Attah-Poku
Life of this patent
Estimating the term…
Abstract
A composition for transdermal and dermal administration of interferon-α is described. The composition is comprised of lipid vesicles including a fatty acylated amino acid and an oil-in-water emulsion. Interferon-α is entrapped in the vesicles.
Claims46
An interferon-α composition, comprising
- biphasic lipid vesicles comprised of (i) a lipid bilayer comprising a phospholipid and a fatty acylated amino acid;
- (ii) an oil-in-water emulsion entrapped in the biphasic lipid vesicles, said oil-in-water emulsion being stabilized by a surfactant;
- and (iii) interferon-α entrapped in said vesicles;
- said fatty acylated amino acid being represented by the formula:
- wherein R1 is an acyl group having from 1-20 carbons, R2 is hydrogen or an alkyl group, and R3 corresponds to a modified or unmodified R group of an amino acid selected from the group consisting of glycine, alanine, serine, aspartic acid, arginine, valine, threonine, glutamic acid, leucine, cysteine, histidine, lsoleucine, tyrosine, asparagine, methionine, proline, tryptophan, phenylalanine, and glutamine;
- wherein said composition when applied to the skin of a subject being effective to administer a therapeutically effective amount of interferon-α.
3 more elements
An interferon-α composition, comprising
- biphasic lipid vesicles comprised of (i) a lipid bilayer comprised of a phospholipid and an acylated amino acid represented by the formula:
- wherein R1 is an acyl group having from 1-20 carbons, R2 is hydrogen or an alkyl group, and R3 corresponds to a modified or unmodified R group of an amino acid selected from the group consisting of glycine, alanine, serine, aspartic acid, arginine, valine, threonine, glutamic acid, leucine, cysteine, histidine, isoleucine, tyrosine, asparagine, methionine, proline, tryptophan, phenylalanine, and glutamine;
- (ii) an oil-in-water emulsion entrapped in the biphasic lipid vesicles, said oil-in-water emulsion comprised of a triglyceride that is dispersed in a water phase containing a fatty alcohol and that is stabilized by a surfactant;
- and (iii) interferon-α entrapped in said vesicles;
- wherein said composition when applied to the skin of a subject being effective to administer a therapeutically effective amount of interferon-α.
2 more elements
An interferon-α composition, comprising
- biphasic lipid vesicles comprised of (i) a lipid bilayer comprising a phospholipid and a fatty acylated amino acid;
- (ii) an oil-in-water emulsion entrapped in the biphasic lipid vesicles, said oil-in-water emulsion being stabilized by a surfactant;
- and (iii) interferon-α entrapped in said vesicles;
- said fatty acylated amino acid being represented by the formula:
- wherein
- R1 is hydrogen or an acyl group having less than 16 carbons and R2 is hydrogen or an alkyl group, but when R1 is hydrogen, R2 is an alkyl group, and R3 corresponds to a modified or unmodified lysine R group;
- wherein said composition when applied to a subject being effective to administer a therapeutically effective amount of interferon-α.
4 more elements
An interferon-α composition, comprising biphasic lipid vesicles comprised of (i) a lipid bilayer comprised of a phospholipid and an acylated amino acid represented by the formula:
- wherein R1 is hydrogen or an acyl group having less than 16 carbons and R2 is hydrogen or an alkyl group, but when R1 is hydrogen, R2 is an alkyl group, and R3 corresponds to a modified or unmodified lysine R group;
- (ii) an oil-in-water emulsion entrapped in the biphasic lipid vesicles, said oil-in-water emulsion comprised of a triglyceride that is dispersed in a water phase containing a fatty alcohol and that is stabilized by a surfactant;
- and (iii) interferon-α entrapped in said vesicles;
- wherein said composition when applied to a subject being effective to administer a therapeutically effective amount of interferon-α.
1 more element
Dependencies are inferred from the claim text.