US 6,656,498 B1Granted

Cationic liposomes for gene transfer

AssigneeVanderbilt University

InventorXiang Gao

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Abstract

The present invention relates to synthetic cationic lipids, liposome formulations and the use of the compounds to introduce functional bioactive agents into cultured cells.

Claims9

Dependent claims

A cationic lipid compound having the formula:

or a pharmaceutically acceptable salt or ester thereof, wherein R1 and R2 are the same and are from C6 to C24 alkyl or C6 to C24 alkenyl.

Dependencies are inferred from the claim text.

Facts

Application: 09/447,688Filed 23 Nov 1999 · us provisional application
Priority: 25 Nov 1998
Granted: 2 Dec 2003
Term ends: Not estimatedThe source records don’t support an estimate.

Classification35 codes

C07D 295/088
With the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings: to…
A61K 9/1272
Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers: comprising non-phosphatidyl surfactants as…
A61K 48/0025
Characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered…: wherein…
C07C 211/09
Of an acyclic saturated carbon skeleton: diamines

Family

Application60/109,950Us provisional application · filed 25 Nov 1998
Application60/110,970Us provisional application · filed 4 Dec 1998
US 6,656,498 B1This patent

From the US filing history. Foreign family members aren’t listed.

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