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US 6,656,496 B1Granted
Porous tissue scaffolding materials and uses thereof
AssigneeThe UAB Research Foundation
InventorsDeepak V. Kilpadi, Dale S. Feldman, Shu T. Huang, Barbara Blum
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Abstract
A biodegradable scaffold includes a protein, a cross-linking agent, 10 to 50 percent by volume porosity imparting polymeric beads and a modifying agent. A method for the use of the biodegradable scaffold is also provided.
Claims16
A bioadhesive scaffold material, said material comprising:
- albumin;
- a polyethylene glycol crosslinking agent;
- 10 to 50 volume percent of 10 to 500 micron polymeric beads imparting porosity, said beads selected from the group consisting of:
- polyethylene glycol and poly(ethylene oxide);
- and
- a modifying agent incorporated into said bioadhesive material, wherein said modifying agent is selected from the group consisting of:
- a tissue growth promoting agent fibroblast growth factor I (FGF-I), an anti-inflammatory and an antibiotic.
4 more elements
Dependencies are inferred from the claim text.