Spill resistant pharmaceutical system

A ready-to-use pharmaceutical delivery system comprising a squeezable container containing a formulation from which a unit dose of the formulation may be squeezed, the formulation comprising a pharmaceutical agent in a vehicle comprising a liquid base comprising from about 30% to about 50% glycerin, and a thickening agent, the formulation consisting of mutually compatible components and having the following properties:

• an initial viscosity within the range of about 5,000 cps to about 12,500 cps;
• a viscometric yield value of a semi-solid;
• a spill-resistant consistency permitting the formulation to be squeezed by light manual pressure through a channel of about one to about five mm, to spread in a spoon bowl sufficiently quickly for accurate measurement;
• homogeneity wherein the components do not separate under conditions of use;
• and
• storage stability for at least three months of storage at elevated temperature, with viscosity remaining within a range of 50% less to 100% more than the initial viscosity.

A ready-to-use pharmaceutical delivery system comprising a squeezable container containing a formulation from which a unit dose of the formulation may be squeezed, the formulation comprising a pharmaceutical composition comprising:

• a water-soluble carboxyvinyl polymer in an amount of 1.0% by weight or less;
• a liquid base comprising glycerin and/or propylene glycol;
• and
• a pharmaceutical agent,
• the composition being a homogeneous semi-solid and dispensable from a squeezable container, and having a viscosity of less than about 12,000 cps.