Cross-protective salmonella vaccines
OwnerSamuel D. Charles, Albert Surendran Abraham +1inventors
InventorsSamuel D. Charles, Albert Surendran Abraham, Emilio Trigo-Tavera
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Abstract
The present invention relates to a method of protecting pigs against disease caused by infection by heterologous serotypes of Salmonella including but not limited to S. typhimurium comprising administering to the pigs a modified live vaccine incorporating S. cholerasuis.
Claims3
A method of immunizing swine to reduce the effects of infection by Salmonella typhimurium, comprising administering an effective amount of an avirulent Salmonella cholerasuis, wherein the avirulent Salmonella cholerasuis has deletions in the cya, crp and cdt genes, whereby said avirulent Salmonella cholerasuis does not produce functional adenylate cyclase or functional cyclic AMP receptor protein.
Dependencies are inferred from the claim text.