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AssigneeThe Johns Hopkins University School of Medicine
InventorsSe-Jin Lee, Alexandra C. McPherron
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The present invention provides a substantially purified growth differentiation factor (GDF) receptor, including a GDF-8 (myostatin) receptor, as well as functional peptide portions thereof. In addition, the invention provides a virtual representation of a GDF receptor or a functional peptide portion thereof. The present invention also provides a method of modulating an effect of myostatin on a cell by contacting the cell with an agent that affects myostatin signal transduction in the cell. In addition, the invention provides a method of ameliorating the severity of a pathologic condition, which is characterized, at least in part, by an abnormal amount, development or metabolic activity of muscle or adipose tissue in a subject, by modulating myostatin signal transduction in a muscle cell or an adipose tissue cell in the subject. The invention also provides a method of modulating the growth of muscle tissue or adipose tissue in a eukaryotic organism by administering an agent that affects myostatin signal transduction to the organism.
A method of reducing or inhibiting an effect of myostatin on a cell, comprising contacting the cell with a myostatin prodomain, which alters a specific interaction of myostatin with a myostatin receptor expressed by the cell, said myostatin prodomain consisting of about amino acid residues 20 to 262 of a promyostatin polypeptide selected from the group consisting of SEQ ID NOS:
A method of ameliorating the severity of a pathologic condition characterized, at least in part, by an abnormal amount, development or metabolic activity of muscle in a subject, said method comprising contacting a muscle cell in the subject with a myostatin prodomain, said myostatin prodomain consisting of about amino acid residues 20 to 262 of a promyostatin polypeptide as set forth in any of SEQ ID NOS:
A method of increasing the growth of muscle tissue in a eukaryotic organism, comprising administering to the organism a myostatin prodomain, said myostatin prodomain consisting of about amino acid residues 20 to 262 of a promyostatin polypeptide as set forth in any of SEQ ID NOS:
Dependencies are inferred from the claim text.