Ultra high affinity neutralizing antibodies
AssigneesMedImmune, LLC, Applied Molecular Evolution, Inc.
InventorsJames F. Young, Leslie S. Johnson, William D. Huse, Herren Wu, Jeffry D. Watkins
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Abstract
Ultra high affinity antibodies with binding affinities in the range of 1010 M−1, and even 1011 M−1 are disclosed. Such antibodies include antibodies having novel high affinity complementarity determining regions (CDRs), especially those with framework and constant regions derived from either humans or mice. Methods of preparing and screening such antibodies, as well as methods of using them to prevent and/or treat disease, especially virus-induced diseases, are also disclosed.
Claims20
An isolated neutralizing anti-RSV (respiratory syncytial virus) antibody, or active fragment thereof, wherein said antibody has an affinity constant of at least 1010 M−1.
Dependencies are inferred from the claim text.