US 6,656,465 B2Granted

Antibodies that mimic actions of neurotrophins

AssigneeThe Regents of the University of California

InventorsDouglas O. Clary, Gisela Weskamp, Leeann R. Austin, Louis F. Reichardt

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Abstract

The use and production of immunoglobulins which activate trk receptors and imitate effects of neurotrophins are provided. Immunoglobulins which block trk receptor activation and methods of use are also provided.

Claims6

Dependent claims

A method for activating a trk receptor comprising exposing cells having the trk receptor to a multivalent immunoglobulin which binds to the receptor and activates the receptor.

Dependencies are inferred from the claim text.

Facts

Application: 09/770,949Filed 26 Jan 2001 · continuation
Priority: 3 Dec 1993
Published: US 2002/0054874 A19 May 2002
Granted: 2 Dec 2003
Term ends: Not estimatedThe source records don’t support an estimate.

Classification8 codes

C07K 16/28
Against material from animals or humans: against receptors, cell surface antigens or cell surface determinants
C07K 14/705
From animals; from humans: receptors; Cell surface antigens; Cell surface determinants
G01N 33/6896
Related to diseases not provided for elsewhere: neurological disorders, e.g. Alzheimer's disease
A61K 38/00
Medicinal preparations containing peptides

Family

Application08/162,597Parent of this continuation · filed 3 Dec 1993
Application08/466,839Parent of this continuation · filed 6 Jun 1995
Application09/033,313Parent of this continuation · filed 2 Mar 1998
US 2002/0054874 A1Pre-grant publication · published 9 May 2002
US 5,753,225 AParent of this continuation
US 6,656,465 B2This patent

From the US filing history. Foreign family members aren’t listed.

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