Interleukin-1 muteins useful as vaccine adjuvants
OwnerRichard S. Dondero, Herman F. Staatsinventors
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Abstract
The present invention concerns compositions comprising an IL-1 mutein that is useful as an adjuvant for stimulating a controlled immune response when administered to a human or animal. For example, muteins of IL-1β can be used according to the invention. The mutein composition can include a vaccine antigen, such as whole inactivated or attenuated virus, recombinant or synthetic peptides, and other antigenic materials. The present invention also pertains to the use of an IL-1 mutein in a human or animal as an adjuvant to increase immune responses to an antigen or other material to which an immune response is desired.
Claims4
A composition for stimulating immune response in a subject comprising:
- an antigen, and
- a mutein of human interleukin-1β (IL-1 β) in which the arginine at position 127 of precursor IL-1 β has been replaced with another amino acid,
- wherein the IL-1β mutein has reduced toxicity to a human compared to the corresponding wild-type IL-1β.
A composition for stimulating an immune response in a subject comprising
- an antigen, and
- a mutein of human interleukin-1β (IL-1β) in which the arginine at position 11 of mature IL-1β has been replaced with another amino acid,
- wherein the IL-1β mutein has reduced toxicity to a human compared to the corresponding wild-type IL-1β.
Dependencies are inferred from the claim text.