Method and composition for dry eye treatment
AssigneesYissum Research Development Company, Company of the Hebrew University of Jerusalem Novagali S.A.S.
InventorsSimon Benita, Gregory Lambert
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Abstract
A method and composition for treating a dry eye condition by topically applying to the eye surfaces an emulsion forming a tear film that acts to lubricate the eye and to inhibit evaporation therefrom. The emulsion is constituted by water in which is dispersed a mixture that includes a phospholipid, a non-polar oil, a non-toxic emulsifying agent and a polar lipid that imparts a net positive charge to the film that is distributed throughout the film, causing the film to be electrostatically attracted to the anionic surface of the eye whereby the film adheres thereto and cannot be washed away. Includable in the mixture is a non-soluble therapeutic agent, such as cyclosporin which is effective against an eye disease and is delivered to the eye by the film.
Claims15
A method of treating a dry eye condition comprising:
- preparing an emulsion in which water has dispersed therein a mixture including a non-polar phospholipid, a non-polar oil, a non-toxic emulsifying agent, and a cationic lipid which imparts to the emulsion a net positive charge;
- and
- topically applying the emulsion to an eye surface to form a tear film which is electrostatically attracted to the anionic surface of the eye whereby the film adheres to the surface;
- wherein the emulsion is prepared to create submicron droplets thereof.
A method of treating a dry eye condition comprising:
- preparing an emulsion in which water has dispersed therein a mixture including a non-polar phospholipid, a non-polar oil, a non-toxic emulsifying agent, a water-insoluble medicament, and a cationic lipid which imparts to the emulsion a net positive charge;
- and
- topically applying the emulsion to an eye surface to form a tear film which is electrostatically attracted to the anionic surface of the eye whereby the film adheres to the surface.
Dependencies are inferred from the claim text.