Use of inhaled NO as anti-inflammatory agent
AssigneeThe General Hospital Corporation
InventorsWarren M. Zapol, Kenneth D. Bloch
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Abstract
A method for lessening or preventing non-pulmonary ischemia-reperfusion injury or inflammation in a mammal by identifying a mammal which has ischemia-reperfusion or is at risk for developing ischemia-reperfusion in a non-pulmonary tissue; and causing the mammal to inhale a therapeutically effective amount of gaseous nitric oxide sufficient to diminish the ability of leukocytes or platelets to become activated in a manner that contributes to an inflammatory process at the site of the ischemia-reperfusion or inflammation in the non-pulmonary tissue, thereby lessening or preventing non-pulmonary ischemia-reperfusion injury in the mammal.
Claims16
A method for treating non-pulmonary ischemia-reperfusion injury in a mammal, comprising the steps of:
- (a) identifying a mammal that has ischemia-reperfusion injury in a non-pulmonary tissue;
- and
- (b) causing the mammal to inhale a therapeutically effective amount of gaseous nitric oxide sufficient to diminish the ability of the mammal's leukocytes or platelets to become activated in a manner that contributes to an inflammatory process at the site of the ischemia-reperfusion in the non-pulmonary tissue, and
- (c) administering to the mammal a therapeutically effective amount of a second compound that potentiates the therapeutic effect of gaseous nitric oxide.
Dependencies are inferred from the claim text.