Indole compounds as novel dyes for organ function monitoring
AssigneeMallinckrodt Inc.
InventorsSamuel Achilefu, Raghavan Rajagopalan, Richard B. Dorshow, Joseph E. Bugaj
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Abstract
Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function monitoring. Particularly, the molecules of the invention are useful for optical diagnosis of renal and cardiac diseases and for estimation of blood volume in vivo.
Claims2
A composition comprising a pharmaceutically acceptable formulation of an indole having the formula
- wherein each of R46, R48, R50, R51, R52 and R53, R55, and R57 is H;
- each of R47, R49, and R56 is SO3T;
- R58 is glucose;
- each of Y5 and Z6 is —(CH2)3SO3T;
- each of W6 and X6 is —C(CH2OH)2;
- D6 is a double bond;
- each of B6 and E6 is —CH—;
- A6 is —CH2—;
- each of a6 ands b6 is 1;
- V5 a single bond;
- and T is a negative charge.
A method for performing a diagnostic or therapeutic procedure comprising administering to a mammal an effective amount of an indole compound having the formula
- wherein each of R46, R48, R50, R51, R52 and R53, R55, and R57 is H;
- each of R47, R49, R54, and R56 is SO3T;
- R58 is glucose;
- each of Y5 and Z6 is —(CH2)3SO3T;
- each of W6 and X6 is —C(CH2OH)2;
- D6 is a double bond;
- each of B6 and E6 is —CH—;
- A6 is —CH2—;
- each of a6 ands b6 is 1;
- V5 is a single bond;
- and T is a negative charge;
- and performing the diagnostic or therapeutic procedure.
Dependencies are inferred from the claim text.