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US 6,656,450 B2Granted
Macrocyclic magnetic resonance imaging contrast agents
AssigneeCalifornia Institute of Technology
InventorsTimothy J. Hubin, Thomas J. Meade
Life of this patent
Estimating the term…
Abstract
The invention relates to novel magnetic resonance imaging contrast agents.
Claims10
A chelating agent comprising a compound having the formula:
- wherein
- A—B is a structure selected from the group consisting of —CR2—CR2—, —CR═CR—, —CR2—CR2—CR2—, CR═CR—CR2— and —CR2—CR═CR, and wherein at least one A—B structure is —CR═CR—;
- X1 and X2 are independently selected from the group consisting of CR2COOH, and CR(CR2COOH)2;
- each R is independently selected from the group consisting of hydrogen, alkyl, aryl, alcohol, amine, amido, nitro, ether, ester, ketone, imino, aldehyde, alkoxy, carbonyl, halogen, sulfur containing moiety, phosphorus containing moiety, targeting moiety, or, together with an adjacent R group forms an alkyl or aryl group;
- or a salt thereof.
2 more elements
An MRI composition comprising a compound having the formula:
- wherein
- A—B is a structure selected from the group consisting of —CR2—CR2—, —CR═CR—, —CR2—CR2—CR2—, CR═CR—CR2— and —CR2—CR═CR, and wherein at least one A—B structure is —CR═CR—;
- X1 and X2 are independently selected from the group consisting of CR2 COO−, and CR(CR2COO−)2;
- each R is independently selected from the group consisting of hydrogen, alkyl, aryl, alcohol, amine, amido, nitro, ether, ester, ketone, imino, aldehyde, alkoxy, carbonyl, halogen, sulfur containing moiety, phosphorus containing moiety, targeting moiety, or, together with an adjacent R group forms an alkyl or aryl group;
- and a paramagnetic ion;
- or a salt thereof.
3 more elements
An MRI composition comprising a compound having a formula:
- wherein a hydrogen is attached at all positions capable of having one or more R groups attached;
- and a paramagnetic ion;
- or a salt thereof.
Dependencies are inferred from the claim text.