Apparatus and method for preparative supercritical fluid chromatography

An apparatus to collect liquid samples from a biphasic flow stream, comprising:

• at least one collection chamber with an opening at the top end;
• a frame;
• a moveable lid;
• a plurality of phase transfer points through apertures in said lid corresponding to said open end of said collection chamber;
• a sample discharge port in said collection chamber;
• transfer tubes comprising an inlet tube carrying said biphase fluid into said collection chamber and an outlet tube carrying gaseous phase out of said collection chamber;
• each said collection chamber secured into said frame and said lid covering said collection chamber removably secured to said frame.

An apparatus collecting samples from a biphasic flow stream, comprising:

• at least one collection chamber open at one end;
• at least one removable collection liner housed inside of said collection chamber;
• a support frame;
• a moveable lid covering said collection chamber, said lid having apertures through said lid corresponding to the open end of said collection chamber;
• a sample discharge port through a wall of said collection chamber for removing liquid phase from said chamber;
• transfer tubes comprising an inlet tube carrying said biphase fluid into said collection chamber and an outlet tube carrying gaseous phase out of said collection chamber;
• said support frame securing said collection chamber in an upright position.

An apparatus collecting samples from a biphasic flow stream, comprising:

• a plurality of collection chambers, having at least one opening to each said chamber;
• a chamber liner for each said chamber;
• a support frame securing said collection chambers into a cassette bank;
• at least one actuator connected to said cassette;
• a moveable lid covering said collection chamber;
• at least one actuator connected to said moveable lid;
• said lid having apertures through corresponding to said opening of said collection chambers;
• a programmable robotic arm;
• said actuator engages said moveable lid to said frame thereby covering said chambers;
• said robotic arm exchanges chamber liners within said collection chambers of said cassette.