Synovial fluid control
AssigneeQuantimetrix
InventorRobert W. Ban
Life of this patent
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Abstract
A control reference material for the measurement of cells and crystals that are present in synovial fluid at different pathognomic conditions. Several possible suspending buffers for the control, its methods of preparation and a method for using these controls for analyses are provided. These controls are less costly and more readily available in greater quantities than current controls prepared from normal human synovial fluid as the suspending base.
Claims30
A pathognomic synovial fluid reference control material for the quality control of tests detecting positive birefringent crystal induced joint diseases in a suspending base unreactive to crystal or cell or a combination of crystal and cell, comprising fixed white blood cells and pyrophosphate crystals in a suspending base containing potassium chloride, the suspending base unreactive to crystal or cell or a combination of crystal and cell.
A pathognomic synovial fluid reference control material for the quality control of tests detecting negative birefringent crystal induced joint diseases in a suspending base unreactive to crystal or cell or a combination of crystal and cell, comprising fixed white blood cells and urate crystals in a suspending base containing potassium chloride, the suspending base unreactive to crystal or cell or a combination of crystal and cell.
A method of preparing a pathognomic, synovial reference control material at pH 7.0±1.0, comprising:
- dissolving pyrophosphate crystals and fixed white blood cells in a suspending base containing potassium chloride unreactive to crystals or cell or a combination of crystal and cell.
A method of preparing a pathognomic synovial reference control material at pH 7.0±1.0, comprising:
- dissolving urate crystals and fixed white blood cells in a suspending base containing potassium chloride unreactive to crystals or cell or a combination of crystal and cell.
Dependencies are inferred from the claim text.