Back to results
US 6,653,091 B1Granted
Method and device for predicting physiological values
AssigneeCyngnus, Inc.
InventorsTimothy C. Dunn, Yalia Jayalakshmi, Ronald T. Kurnik, Matthew J. Lesho, Jonathan James Oliver, Russell O. Potts, Janet A. Tamada, Steven Richard Waterhouse, Charles W. Wei
Life of this patent
Estimating the term…
Abstract
The invention relates generally to methods, systems, and devices for measuring the concentration of target analytes present in a biological system using a series of measurements obtained from a monitoring system and a Mixtures of Experts (MOE) algorithm. In one embodiment, the present invention describes a method for measuring blood glucose in a subject.
Claims23
A method for measuring glucose present in a biological system, said method comprising:
- transdermally extracting a sample comprising glucose from the biological system using a sampling system that is in operative contact with a skin or mucosal surface of said biological system;
- obtaining a raw signal from the extracted glucose, wherein said raw signal is specifically related to glucose amount or concentration in the biological system;
- performing a calibration which correlates the raw signal with a measurement value indicative of the amount or concentration of glucose present in the biological system at the time of extraction;
- repeating said transdermal extracting and said obtaining a raw signal to obtain a series of two or more measurement values at selected time intervals;
- and
- predicting a measurement value based on the series of measurement values using a Mixtures of Experts algorithm comprising the following
- BG=w1BG1+w2BG2+w3BG3 (15)
- wherein (BG) is blood glucose, BGi is the blood glucose predicted by Expert i;
- wi is a weighting value, and the individual Experts BGi are further defined by the expression shown as Equations 16, 17, and 18
- BG1=p1(timec)+q1(active)+r1(signal)+s1(BG|cp)+t1 (16)
- BG2=p2(timec)+q2(active)+r2(signal)+s2(BG|cp)+t2 (17)
- BG3=p3(timec)+q3(active)+r3(signal)+s3(BG|cp)+t3 (18)
- wherein, BGi is the blood glucose predicted by Expert i;
- parameters include, timec (elapsed time from a calibration of said sampling system), active (active signal), signal (calibrated signal), and BG/cp (blood glucose value at a calibration point);
- pi, qi, ri, and si are coefficients;
- and ti is a constant;
- and further where the weighting value, wi, is defined by the formulas shown as Equations 19, 20, and 21 w 1 = ⅇ d 1 ⅇ d 1 + ⅇ d 2 + ⅇ d 3 ( 19 ) w 2 = ⅇ d 2 ⅇ d 1 + ⅇ d 2 + ⅇ d 3 ( 20 ) w 3 = ⅇ d 3 ⅇ d 1 + ⅇ d 2 + ⅇ d 3 ( 21 )
- where e refers to the exponential function and di is a parameter set used to determine the weights wi, given by Equations 19, 20, and 21, and
- d1=τ1(timec)+β1(active)+gamma1(signal)+δ1(BG|cp)+ε1 (22)
- d2=τ2(timec)+β2(active)+gamma2(signal)+δ2(BG|cp)+ε2 (23)
- d3=τ3(timec)+β3(active)+gamma3(signal)+δ3(BG|cp)+ε3 (24)
- where τi, βi, gammai and δi are coefficients, and where εi is a constant.
19 more elements
A method for measuring glucose in a subject, said method comprising:
- obtaining a raw signal from a sensing apparatus, wherein said raw signal is specifically related to an amount or concentration of glucose in the subject;
- performing a calibration which correlates the raw signal with a measurement value indicative of the glucose amount or concentration in the subject;
- repeating said obtaining of raw signal to obtain a series of measurement values at selected time intervals;
- and
- predicting a measurement value using a Mixtures of Experts algorithm comprising the following,
- BG=w1BG1+w2BG2+w3BG3 (15)
- wherein (BG) is blood glucose, BGi is the blood glucose predicted by Expert i;
- wi is a weighting value, and the individual Experts BGi are further defined by the expression shown as Equations 16, 17, and 18
- BG1=p1(timec)+q1(active)+r1(signal)+s1(BG|cp)+t1 (16)
- BG2=p2(timec)+q2(active)+r2(signal)+s2(BG|cp)+t2 (17)
- BG3=p3(timec)+q3(active)+r3(signal)+s3(BG|cp)+t3 (18)
- wherein, BGi is the blood glucose predicted by Expert i;
- parameters include, timec (elapsed time from a calibration of said sampling system), active (active signal), signal (calibrated signal), and BG/cp (blood glucose value at a calibration point);
- pi, qi, ri, and si are coefficients;
- and ti is a constant;
- and further where the weighting value, wi, is defined by the formulas shown as Equations 19, 20, and 21 w 1 = ⅇ d 1 ⅇ d 1 + ⅇ d 2 + ⅇ d 3 ( 19 ) w 2 = ⅇ d 2 ⅇ d 1 + ⅇ d 2 + ⅇ d 3 ( 20 ) w 3 = ⅇ d 3 ⅇ d 1 + ⅇ d 2 + ⅇ d 3 ( 21 )
- where e refers to the exponential function and di is a parameter set used to determine the weights wi, given by Eguations 19, 20, and 21, and
- d1=τ1(timec)+β1(active)+gamma1(signal)+δ1(BG|cp)+ε1 (22)
- d2=τ2(timec)+β2(active)+gamma2(signal)+δ2(BG|cp)+ε2 (23)
- d3=τ3(timec)+β3(active)+gamma3(signal)+δ3(BG|cp)+ε3 (24)
- where τi, βi, gammai and δi are coefficients, and where εi is a constant.
18 more elements
A monitoring system for measuring glucose present in a biological system, said monitoring system comprising, in operative combination:
- a sampling device for extracting a sample comprising glucose from the biological system, wherein said sampling device extracts the sample across a skin or mucosal surface of said biological system;
- a sensing device in operative contact with the sample extracted by the sampling device, wherein said sensing device obtains a raw signal from the extracted glucose and said raw signal is specifically related to an amount or concentration of glucose present in the biological system;
- and
- one or more microprocessors in operative communication with the sampling device and the sensing device, wherein said microprocessors (i) control the sampling device and the sensing device to obtain a series of raw signals at selected time intervals during a measurement period, (ii) correlate the raw signals with measurement values indicative of the amount or concentration of glucose present in the biological system, and (iii) predict a measurement value using a Mixtures of Experts algorithm comprising the following,
- BG=w1BG1+w2BG2+w3BG3 (15)
- wherein (BG) is blood glucose, BGi is the blood glucose predicted by Expert i;
- wi is a weighting value, and the individual Experts BGi are further defined by the expression shown as Equations 16, 17, and 18
- BG1=p1(timec)+q1(active)+r1(signal)+s1(BG|cp)+t1 (16)
- BG2=p2(timec)+q2(active)+r2(signal)+s2(BG|cp)+t2 (17)
- BG3=p3(timec)+q3(active)+r3(signal)+s3(BG|cp)+t3 (18)
- wherein, BGi is the blood glucose predicted by Expert i;
- parameters include, timec (elapsed time from a calibration of said sampling system), active (active signal), signal (calibrated signal), and BG/cp (blood glucose value at a calibration point);
- pi, qi, ri, and si are coefficients;
- and ti is a constant;
- and further where the weighting value, wi, is defined by the formulas shown as Equations 19, 20, and 21 w 1 = ⅇ d 1 ⅇ d 1 + ⅇ d 2 + ⅇ d 3 ( 19 ) w 2 = ⅇ d 2 ⅇ d 1 + ⅇ d 2 + ⅇ d 3 ( 20 ) w 3 = ⅇ d 3 ⅇ d 1 + ⅇ d 2 + ⅇ d 3 ( 21 )
- where e refers to the exponential function and di is a parameter set used to determine the weights wi, given by Equations 19, 20, and 21, and
- d1=τ1(timec)+β1(active)+gamma1(signal)+δ1(BG|cp)+ε1 (22)
- d2=τ2(timec)+β2(active)+gamma2(signal)+δ2(BG|cp)+ε2 (23)
- d3=τ3(timec)+β3(active)+gamma3(signal)+δ3(BG|cp)+ε3 (24)
- where τi, βi, gammai and δi are coefficients, and where εi is a constant.
17 more elements
A monitoring system for measuring glucose in a subject, said system comprising, in operative combination:
- a sensing device in operative contact with a sample extracted from the subject, said sample comprising glucose, wherein said sensing device obtains a raw signal specifically related to an amount or concentration of glucose in the subject;
- and
- one or more microprocessors in operative communication with the sensing device, wherein said microprocessors (i) control the sensing device to obtain a series of raw signals at selected time intervals, (ii) correlate the raw signals with measurement values indicative of the amount or concentration of glucose present in the subject, and (iii) predict a measurement value using a Mixtures of Experts algorithm comprising the following,
- BG=w1BG1+w2BG2+w3BG3 (15)
- wherein (BG) is blood glucose, BGi is the blood glucose predicted by Expert i;
- wi is a weighting value, and the individual Experts BGi are further defined by the expression shown as Equations 16, 17, and 18
- BG1=p1(timec)+q1(active)+r1(signal)+s1(BG|cp)+t1 (16)
- BG2=p2(timec)+q2(active)+r2(signal)+s2(BG|cp)+t2 (17)
- BG3=p3(timec)+q3(active)+r3(signal)+s3(BG|cp)+t3 (18)
- wherein, BGi is the blood glucose predicted by Expert i;
- parameters include, timec (elapsed time from a calibration of said sampling system), active (active signal), signal (calibrated signal), and BG/cp (blood glucose value at a calibration point);
- pi, qi, ri, and si are coefficients;
- and ti is a constant;
- and further where the weighting value, wi, is defined by the formulas shown as Equations 19, 20, and 21 w 1 = ⅇ d 1 ⅇ d 1 + ⅇ d 2 + ⅇ d 3 ( 19 ) w 2 = ⅇ d 2 ⅇ d 1 + ⅇ d 2 + ⅇ d 3 ( 20 ) w 3 = ⅇ d 3 ⅇ d 1 + ⅇ d 2 + ⅇ d 3 ( 21 )
- where e refers to the exponential function and di is a parameter set used to determine the weights wi, given by Equations 19, 20, and 21, and
- d1=τ1(timec)+β1(active)+gamma1(signal)+δ1(BG|cp)+ε1 (22)
- d2=τ2(timec)+β2(active)+gamma2(signal)+δ2(BG|cp)+ε2 (23)
- d3=τ3(timec)+β3(active)+gamma3(signal)+δ3(BG|cp)+ε3 (24)
- where τi, βi, gammai and δi are coefficients, and where εi is a constant.
16 more elements
Dependencies are inferred from the claim text.