Biodegradable cationic copolymers of poly (alkylenimine) and poly (ethylene glycol) for the delivery of bioactive agents
AssigneeExpression Genetics, Inc.
InventorsCheol Hee Ahn, Sung Wan Kim
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Abstract
A biodegradable, novel cationic coopolymer comprising a a poly(alkylenimine)(PAI), a hydrophilic polymer, and a biodegradable linker, wherein the biodegradable linker covalently links the PAI and the hydrophilic polymer. The biodegradable cationic copolymers in the present invention can be used in drug delivery and are especially useful for delivery of a nucleic acid or any anionic bioactive agent to various organs and tissues after local or systemic administration.
Claims27
A linear biodegradable cationic multi-block copolymer comprising alternating blocks of poly(alkylenimine)(PAI) and hydrophilic polymers with the end blocks of the copolymer being PAI, wherein said PAI is linked with said hydrophilic polymer by a biodegradable bond and wherein said biodegradable cationic copolymer is free of cross linkages and is synthesized by reacting PAI with hydrophilic polymers having difunctional groups.
A linear biodegradable cationic multi-block copolymer comprising alternating blocks of poly(alkylenimine)(PAI) and hydrophilic polymers with the end blocks of the copolymer being PAI, wherein said PAI is linked with said hydrophilic polymer by a biodegradable ester or amide bond, and wherein said biodegradable cationic copolymer is free of cross linkages and is synthesized by reacting PAI with hydrophilic polymers having difunctional groups.
A linear biodegradable cationic multi-block copolymer comprising alternating blocks of poly(ethylenimine)(PEI) and hydrophilic polymers with the end blocks of the copolymer being PEI, wherein said PEI is linked with said hydrophilic polymer by a biodegradable ester or amide bond, and wherein said biodegradable cationic copolymer is free of cross linkages and is synthesized by reacting PEI with hydrophilic polymers having difunctional groups.
A linear biodegradable cationic multi-block copolymer comprising alternating blocks of poly(ethylenimine)(PAI) and hydrophilic polymers which are selected from the group consisting of polyethylene glycol (PEG), polypropylene glycol, poloxamers, poly(acrylic acid), poly(styrene sulfonate), carboxymethylcellulose, poly(vinyl alcohol), polyvinylpyrrolidone, alpha-substituted poly(oxyalkyl) glycols and copolymers of poly(oxyalkyl) glycol, with the end blocks of the block copolymer being PAI, wherein said PAI is linked with said hydrophilic polymer by a biodegradable ester or amide bond and wherein said biodegradable cationic copolymer is free of cross linkages and is synthesized by reacting PAI with hydrophilic polymers having difunctional groups.
A linear biodegradable cationic multi-block copolymer comprising alternating blocks of poly(ethylenimine)(PEI) and hydrophilic polymers which are selected from the group consisting of polyethylene glycol (PEG), polypropylene glycol, poloxamers, poly(acrylic acid), poly(styrene sulfonate), carboxymethylcellulose, poly(vinyl alcohol) and polyvinylpyrrolidone, with the end blocks of the block copolymer being PEI, wherein said PEI is linked with the hydrophilic polymer by a biodegradable ester or amide bond and wherein said biodegradable cationic copolymer is free of cross linkages and is synthesized by reacting PEI with hydrophilic polymers having difunctional groups.
A linear biodegradable cationic multi-block copolymer comprising alternating blocks of poly(ethylenimine)(PAI) and polyethylene glycol (PEG) with the end blocks of the block copolymer being PAI, wherein said PAI is linked with said PEG by a biodegradable ester or amide bond, and wherein said biodegradable cationic copolymer is free of cross linkages and is synthesized by reacting PAI with hydrophilic polymers having difunctional groups.
A linear biodegradable cationic multi-block copolymer comprising alternating blocks of poly(ethylenimine)(PEI) and polyethylene glycol (PEG) with the end blocks of the copolymer being PEI, wherein said PEI is linked with the PEG by a biodegradable ester or amide bond, and wherein said biodegradable cationic copolymer is free of cross linkages and is synthesized by reacting PEI with hydrophilic polymers having difunctional groups.
Dependencies are inferred from the claim text.