Internal introduction of lock masses in mass spectrometer systems

A mass calibration apparatus for a tandem mass spectrometer comprising:

• a collision cell for fragmenting analyte ions;
• and
• a source of lock mass ions adjacent said collision cell for creating lock mass ions in the collision cell.

A mass calibration apparatus for a tandem mass spectrometer comprising:

• ion optics for transporting analyte daughter ions;
• and
• a source of lock mass ions adjacent said ion optics for creating lock mass ions in the ion optics.

A method for mass calibration of analyte ions with lock masses in a mass spectrometer that includes an analyte ion source, ion optics, and a mass analyzer, said method comprising:

• creating lock mass ions within the ion optics.

A method for mass calibration of analyte ions with lock masses in a mass spectrometer that includes an analyte ion source, ion optics and a mass analyzer, said method comprising:

• introducing lock mass molecules into the ion optics;
• and
• ionizing the lock mass molecules within the ion optics.

A method for mass calibration of a tandem mass spectrometer that includes a collision cell, said method comprising:

• creating lock mass ions within the collision cell.

A method for mass calibration of a tandem mass spectrometer that includes a collision cell, said method comprising:

• introducing lock mass molecules into the collision cell;
• and
• ionizing the lock mass molecules within the collision cell.

A method for mass calibration of a tandem mass spectrometer that includes ion optics for transporting analyte daughter ions to a mass analyzer, said method comprising:

• creating lock mass ions within the ion optics.

A method for mass calibration of a tandem mass spectrometer that includes ion optics for transporting analyte daughter ions to a mass analyzer, said method comprising:

• introducing lock mass molecules into the ion optics;
• and
• ionizing the lock mass molecules within the ion optics.