Loading patent…
AssigneeMount Sinai of Medicine of New York University
InventorGiulio M. Pasinetti
Estimating the term…
The invention provides for transgenic mice whose genomes comprise a gene encoding human cyclooxygenase-2 under the control of a neuron-specific promoter. The transgenic mice of the instant invention express human cyclooxygenase-2 mRNA in neuronal cells of their hippocampi at increased levels relative to the level of human cyclooxygenase-2 mRNA expressed in their cerebral white matter. Moreover, neuronal cell cultures derived from the transgenic mice of the instant invention arc more susceptible to aggregated Aβ25-35 peptide-mediated impairment of redox activity relative to those derived from mice non-transgenic for the human cyclooxygenase-2 gene. These transgenic animals and the neuronal cultures derived therefrom are useful iii elucidating the pathophysiological bases of neurodegenerative diseases and in improving the diagnosis and treatment of these disorders.
A transgenic mouse whose genome comprises a gene encoding human cyclooxygenase-2 under the control of a neuron-specific promoter, wherein neuronal cells of the mouse express human cyclooxygenase-2 mRNA, wherein the level of human cyclooxygenase-2 mRNA in the hippocampus of the mouse is increased relative to the level of human cyclooxygenase-2 mRNA in cerebral white matter, and wherein neuronal cell cultures derived from said mouse are more susceptible to aggregated Aβ25-35 peptide-mediated impairment of redox activity relative to those derived from a mouse non-transgenic for the human cyclooxygenase-2 gene.
Dependencies are inferred from the claim text.