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US 6,649,793 B1Granted
Process for the preparation of a N,N-diamino amino acid-β-hydroxy disuccinic acid
AssigneesBoard of Trustees of Michigan State University, Applied CarboChemicals
InventorsCharles Ngowe, Kris A. Berglund
Life of this patent
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Abstract
A process of the preparation of a N,N-diamino amino acid-β-hydroxy-succinic acid as a N,N-diacid salt (I) is described. The process involves reacting epoxy succinic acid with an amino acid having two amino groups as an N-acid salt. The compounds are useful as chelators.
Claims6
A process for the preparation of a N,N-diamino-amino acid-β-hydroxy disuccinic acid (I) which comprises:
- (a) reacting an N-acid salt of an N,N-diamino-amino acid with epoxy succinic acid in an aqueous solvent under substantially acidic conditions to produce (I);
- and
- (b) separating (I) from the reaction mixture.
A process for the preparation of a 2N,6N-lysine-β-hydroxy disuccinic acid which comprises:
- (a) reacting an N-acid salt of lysine with epoxy succinic acid in an aqueous solvent under substantially acidic conditions to produce the 2N,6N-lysine-β-hydroxy disuccinic acid;
- and
- (b) separating the 2N,6N-lysine-β-hydroxy disuccinic acid from the reaction mixture.
Dependencies are inferred from the claim text.