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US 6,649,780 B1Granted
Cationic lipids
AssigneesValentis, Inc., Max-Planck-Gesellschaft zur Foerderung der Wissaschaften B.V.
InventorsHansjörg Eibl, Jinkang Wang, Yi Lin Zhang
Life of this patent
Estimating the term…
Abstract
Cationic lipids are provided which are useful in the preparation of liposomes and other lipid vesicle carriers. The lipids of the invention are particularly useful as carriers of nucleic acids and other negatively charged substances, for delivery to cells.
Claims18
A compound having the formula:
- wherein:
- X11 represents
- R11 and R12 are each independently a C1-C6 alkyl group;
- Z11 is selected from the group consisting of a saturated C1-C26 alkyl group, an unsaturated C3-C26 alkyl group, a saturated C2-C26 acyl group, or an unsaturated C4-C26 acyl group;
- p is 0 to 6;
- Y11 is —CH2—O—R;
- and
- R is selected from the group consisting of a saturated C1-C26 alkyl group, an unsaturated C3-C26 alkyl group, a saturated C2-C26 acyl group, or an unsaturated C4-C26 acyl group;
- providing at least one of either Z11 or R contains a group having at least 14 carbon atoms.
6 more elements
A compound having the formula:
- wherein each R is independently selected from the group consisting of a saturated C8-C26 alkyl group, an unsaturated C8-C26 alkyl group, a saturated C2-C26 acyl group, or an unsaturated C4-C26 acyl group.
Dependencies are inferred from the claim text.