Production methods of imidazole compound and salt thereof and intermediates therefor
AssigneeSumika Fine Chemicals Co., Ltd.
InventorsTetsuya Shintaku, Nobushige Itaya
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Abstract
A production method including a step for converting a halogen compound of the formula (6) or a salt thereof to a glyoxal compound of the formula (2) or a salt thereof in dimethyl sulfoxide, and a step for reacting the glyoxal compound of the formula (2) or a salt thereof obtained in the previous step with ammonia and an aldehyde compound of the formula (3) or a salt thereof can conveniently produce an imidazole compound of the formula (1) or a salt thereof. The imidazole compound is a synthetic intermediate for a compound useful as pharmaceutical agents and agricultural chemicals. The production method is suitable for industrial scale production. is wherein each symbol is as defined in the specification.
Claims4
A production method of an imidazole compound of the formula (1)
- wherein
- R1 is 3-pyridyl;
- and
- R2 is a hydrogen atom, an alkyl group optionally having substituent(s), an unsaturated alkyl group optionally having substituent(s), a cycloalkyl group optionally having substituent(s), an aralkyl group optionally having substituent(s), an arylalkenyl group optionally having substituent(s), an aryl-cyclic hydrocarbon group optionally having substituent(s), an aryl group optionally having substituent(s) or a heterocyclic residue optionally having substituent(s),
- or a salt thereof, which comprises
- (a) converting, in dimethyl sulfoxide, a halogen compound of the formula (6)
- wherein R1 is as defined above, X is a chlorine atom or a bromine atom, m and n are each an integer of 1 or 2, and m+n is 3,
- or a salt thereof, to a glyoxal compound of the formula (2)
- wherein R1 is as defined above,
- or a salt thereof, and
- (b) reacting the glyoxal compound of the formula (2) or a salt thereof obtained in step (a) with ammonia and an aldehyde compound of the formula (3)
- wherein R2 is as defined above,
- or a salt thereof.
Dependencies are inferred from the claim text.