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US 6,649,759 B2Granted
Neuropeptide Y antagonists
AssigneePfizer Inc.
InventorsRichard L. Elliott, Robert M. Oliver, III
Life of this patent
Estimating the term…
Abstract
Compounds of the formula are neuropeptide Y antagonists and are effective in treating feeding disorders, cardiovascular diseases and other physiological disorders related to an excess of neuropeptide Y.
Claims5
A compound of the formula:
- wherein X is
- R1 is phenyl, thienyl or pyridyl each optionally substituted with one to three substituents selected from halogen, —OCF3, NO2, CN, hydroxy, alkylalkoxy, COOH, C1-C6alkyl, C1-C6hydroxyalkyl, C1-C6 aminoalkyl, aryl, heteroaryl, alkoxy, acyloxy,
- NR7R8, C1-C4alkylthio, mono-, di-, or trihaloalkyl, or
- wherein R is phenyl, C1-C6alkyl, hydrogen, OH, or alkoxy;
- R2 is hydrogen or C1-C6alkyl;
- R3 and R4 are independently hydrogen, hydroxyl, —N(C1-C3alkyl)2, C1-C6alkyl, nitro, cyano, or alkylalkoxy, or aryloxy;
- Y is hydrogen, C1-C6alkyl, or pyridyl;
- n is 1 to 3;
- m is 1 to 3;
- and
- R7 and R8 are C1-C6 alkyl;
- with the proviso that when n is 2. Y is hydrogen or C1-C6alkyl;
- and R3 and R4 are both hydrogen, then R1 is not phenyl.
10 more elements
Dependencies are inferred from the claim text.