Process for preparing acarbose with high purity
AssigneeChong Kun Dang Pharmaceutical Corp.
InventorsChung Il Hong, Kyung Hwan Kim, Byoung Taik Choi, Gang Sun Choi, Yong Rack Choi
Life of this patent
Estimating the term…
Abstract
Disclosed herein is a process for preparing highly pure acarbose of formula (I) useful as medicine for the treatment of diabetes. The disclosed process comprises prepurifying an acarbose-containing solution using a synthetic adsorbent to produce a prepurified acarbose having an acarbose content of a predetermined level or more; and contacting the prepurified acarbose with a monodispersed, strongly acid cation exchanger, in one step, to absorb acarbose.
Claims10
A process for preparing highly pure acarbose having an acarbose content of not less than 98%, which comprises the steps of:
- filtering an acarbose-containing fermentation culture;
- adjusting the pH of the filtrate to 3-9;
- contacting the pH-adjusted filtrate with a synthetic adsorbent to adsorb acarbose;
- eluting the adsorbed acarbose with one of distilled water of pH 1-5 and acetone-containing distilled water;
- passing the resulting eluate through an anion exchanger at a high flow rate to decolorize and neutralize the eluate;
- contacting the eluate with a monodispersed, strong acid cation exchanger to adsorb acarbose;
- and
- eluting the adsorbed acarbose with distilled water of pH 1.0-3.0, thereby yielding the highly pure acarbose.
Dependencies are inferred from the claim text.