US 6,649,741 B1 · TADG-15: an extracellular serine protease overexpressed in carcinomas

Abstract

The present invention provides DNA encoding a TADG-15 protein as well as a TADG-15 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression in a recombinant cell and regulatory elements necessary for expression of the DNA in the cell. The present invention further provides for methods of inhibiting TADG-15 expression and/or protease activity methods of detecting TADG-15 mRNA and/or protein and methods of screening for TADG-15 inhibitors. Additionally, the present invention provides for cell-specific targeting via TADG-15 and methods of vaccinating an individual against TADG-15. The methods described are useful in the diagnosis. treatment and prevention of cancer particularly breast and ovarian cancer.

Claims4

Dependent claims

A method of detecting in a sample TADG-15 protein having an amino acid sequence of SEQ ID NO:2, comprising the steps of:

(a) contacting a sample with an antibody specific for TADG-15, wherein said antibody is directed against the carboxy terminus of said TADG-15 protein;
and
(b) detecting binding of said antibody to said TADG-15 protein in said sample.

Dependencies are inferred from the claim text.

Facts

Application

09/654,600Filed 1 Sep 2000 · division

Priority

20 Feb 1998

Granted

18 Nov 2003

Term ends

Not estimatedThe source records don’t support an estimate.

Classification16 codes

C12N 9/6424
From mammals: serine endopeptidases
A61K 40/19
Characterised by the cell type used: dendritic cells
A61K 40/24
Characterised by the effect or the function of the cells: antigen-presenting cells [APC]
A61K 40/4249
Proteinases: serine proteases, e.g. kallikrein

Family

Application09/027,337Parent of this continuation-in-part · filed 20 Feb 1998

Application09/421,213Parent of this division · filed 20 Oct 1999

Application09/421,213Parent of this continuation-in-part

US 5,972,616 AParent of this continuation-in-part

US 7,022,821 B1Related patent

US 6,649,741 B1This patent

From the US filing history. Foreign family members aren’t listed.

TADG-15: an extracellular serine protease overexpressed in carcinomas

Life of this patent

TADG-15: an extracellular serine protease overexpressed in carcinomas

Life of this patent

Abstract

Claims4