Pancreas-derived plasminogen activator inhibitor
AssigneeHuman Genome Sciences, Inc.
InventorsJian Ni, Reiner L. Gentz, Steven M. Ruben
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Abstract
The present invention relates to a novel member of the plasminogen activator inhibitor protein family. In particular, isolated nucleic acid molecules are provided encoding the pancreas-derived plasminogen activator inhibitor protein. Pancreas-derived plasminogen activator inhibitor polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to methods for treating physiologic and pathologic disease conditions, including breast cancer, and diagnostic methods for detecting pathologic disorders.
Claims35
An isolated protein comprising a polypeptide at least 95% identical to an amino acid sequence selected from the group consisting of:
- (a) amino acids −14 to 378 of SEQ ID NO:2;
- (b) amino acids −13 to 378 of SEQ ID NO:2;
- and
- (c) amino acids 1 to 378 of SEQ ID NO:2
- wherein the isolated protein has serine protease inhibitor activity.
An isolated protein, comprising a polypeptide at least 95% identical to an amino acid sequence selected from the group consisting of:
- (a) the full length amino acid sequence as encoded by the cDNA clone contained in American Type Culture Collection (ATCC) Deposit No. 97657;
- and
- (b) the mature amino acid sequence as encoded by the cDNA clone contained in American Type Culture Collection (ATCC) Deposit No. 97657
- wherein the isolated protein has serine protease inhibitor activity.
An isolated protein, comprising a polypeptide at least 95% identical to an amino acid sequence selected from the group consisting of:
- (a) amino acids −18 to 387 of SEQ ID NO:13;
- (b) amino acids −17 to 387 of SEQ ID NO:13;
- and
- (c) amino acids 1 to 387 of SEQ ID NO:13
- wherein the isolated protein has serine protease inhibitor activity.
An isolated protein comprising amino acids 46 to 76 of SEQ ID NO:2, wherein the isolated protein has serine protease inhibitor activity.
Dependencies are inferred from the claim text.