Prodrugs for antimicrobial amidines

A process for making a pharmaceutically active bis-aryl carbamate, said process comprising:

• reacting an aryl carbonate with bis-amidine in the presence of an organic solvent to form the bis-aryl carbamate, wherein the pharmaceutically active bis-aryl carbamate may-se is represented by the formula:
• wherein:
• X is O or S;
• R1 and R2 may be independently selected from the group consisting of H, loweralkyl, oxyalkyl, alkoxyalkyl, cycloalkyl, aryl, hydroxyalkyl, aminoalkyl, and alkylaminoalkyl;
• R3 and R4 are each independently selected from the group consisting of H, loweralkyl, halogen, oxyalkyl, oxyaryl, and oxyarylalkyl;
• R5 is represented by a formula selected from the group consisting of:
• wherein:
• X1, X2, and X3 are independently selected from O and S;
• and
• R6 and R7 are independently selected from the group consisting of loweralkyl, aryl, alkylaryl, oxyaryl, an ester-containing substituent, and oxyalkyl.