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US 6,649,651 B1Granted
Hexahydrofuro[2,3-B]furan-3-yl-n{3[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-benzyl-2-hydroxypropyl}carbamate as retroviral protease inhibitor
AssigneeTibotec Pharmaceuticals Ltd.
InventorsPiet T. B. P. Wigerinck, Guangyang Wang, Michael Eissenstat, John W. Erickson
Life of this patent
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Abstract
Novel bis-tetrahydrofuran benzodioxolyl sulfonamide compounds which are surprisingly effective protease inhibitors. The invention also relates to pharmaceutical compositions, methods of inhibiting retrovirus proteases, in particular multidrug resistant retrovirus proteases, methods of treating or combating infection or disease associated with retrovirus infection in a mammal, and methods of inhibiting viral replication.
Claims17
A compound having the formula
- or an N-oxide, salt, ester, prodrug or metabolite thereof, in any stereoisomeric form, or a mixture of such compounds.
Dependencies are inferred from the claim text.