Heteroaryl phenyl pyrazole compounds as anti-inflammatory/analgesic agents

A compound of the following formula:

• or a pharmaceutically acceptable salt thereof, wherein
• A is pyridine optionally substituted with 1-3 substituents independently selected from the group consisting of halo, hydroxy, cyano, mercapto, carboxy, nitro, (C1-C4)alkyl, (C2-C4)alkenyl, (C2-C4)alkynyl, (C1-C4)alkoxy, (C1-C4)alkyl-S—, amino, (C1-C4)alkylamino, di[(C1-C4)alkyl]amino, amido, (C1-C4)alkylamido, di[(C1-C4)alkyl]amido, (C1-C4)alkyl-(C═O)—O—, (C1-C4)alkyl-(C═O)—N(R′)—, formyl, (C1-C4)alkyl-(C═O)— and (C1-C4)alkoxy-(C═O)—;
• wherein R′ is hydrogen or (C1-C4)alkyl;
• wherein each of said (C1-C4)alkyl may optionally be substituted with 1 to 3 substituents independently selected from the group consisting of halo, hydroxy, cyano, mercapto, carboxy, nitro, (C1-C4)alkyl, (C2-C4)alkenyl, (C2-C4)alkynyl, (C1-C4)alkoxy, (C1-C4)alkyl-S—, amino, (C1-C4)alkylamino, di[(C1-C4)alkyl]amino, amido, (C1-C4)alkylamido, di[(C1-C4)alkyl]amido, (C1-C4)alkyl-(C═O)—O—, (C1-C4)alkyl-(C═O)—N(R′)—, formyl, (C1-C4)alkyl-(C═O)— and (C1-C4)alkoxy-(C═O)—;
• R1 is selected from the group consisting of
• furyl, thiazolyl and oxazolyl which are optionally substituted with 1-3 substituents independently selected from the group consisting of halo, hydroxy, cyano, mercapto, carboxy, nitro, (C1-C4)alkyl, (C2-C4)alkenyl, (C2-C4)alkynyl, (C1-C4)alkoxy, (C1-C4)alkyl-S—, amino, (C1-C4)alkylamino, di[(C1-C4)alkyl]amino, amido, (C1-C4)alkylamido, di[(C1-C4)alkyl]amido, (C1-C4)alkyl-(C═O)—O—, (C1-C4)alkyl-(C═O)—N(R′)—, formyl, (C1-C4)alkyl-(C═O)— and (C1-C4)alkoxy-(C═O)—;
• wherein R′ is hydrogen or (C1-C4)alkyl;
• wherein each of said (C1-C4)alkyl is optionally substituted with 1 to 3 substituents independently selected from the group consisting of halo, hydroxy, cyano, mercapto, carboxy, nitro, (C1-C4)alkyl, (C2-C4)alkenyl, (C2-C4)alkynyl, (C1-C4)alkoxy, (C1-C4)alkyl-S—, amino, (C1-C4)alkylamino, di[(C1-C4)alkyl]amino, amido, (C1-C4)alkylamido, di[(C1-C4)alkyl]amido, (C1-C4)alkyl-(C═O)—O—, (C1-C4)alkyl-(C═O)—N(R′)—, formyl, (C1-C4)alkyl-(C═O)— and (C1-C4)alkoxy-(C═O)—;
• R2 is selected from the group consisting of (C1-C4)alkyl optionally substituted with 1 to 3 halo;
• R3 and R4 are independently selected from the group consisting of hydrogen, halo, (C1-C4)alkyl, (C2-C4)alkenyl, (C1-C4)alkoxy, (C1-C4)alkyl-(C═O)—, cyano, nitro, carboxy, (C1-C4)alkoxy-(C═O)—, amino-(C═O)—, (C1-C4)alkyl-amino-(C═O)—, di[(C1-C4)alkyl]-amino-(C═O)—, N-[(C1-C4)alkyl]—N-phenyl-amino-(C═O)—;
• wherein each of said (C1-C4)alkyl is optionally substituted with 1 to 3 substituents independently selected from the group consisting of halo, hydroxy, cyano, phenyl, and (C1-C4)alkoxy;
• and
• X1, X2, X3 and X4 are independently selected from the group consisting of hydrogen, halo, hydroxy, cyano, mercapto, carboxy, nitro, (C1-C4)alkyl, (C1-C4)alkoxy, (C1-C4)alkyl-S—, (C1-C4)alkyl-amino-, di [(C1-C4)alkyl]-amino-, (C1-C4)alkyl-(C═O)—, (C1-C4)alkoxy-(C═O)— and amino-C(═O)—;
• wherein each said (C1-C4)alkyl is optionally substituted with 1 to 3 substituents independently selected from the group consisting of halo, amino, (C1-C4)alkyl-amino-, di[(C1-C4)alkyl]-amino-, hydroxy, carboxy, amino-(C═O)—, (C1-C4)alkyl-amino-C(═O)—, di[(C1-C4)alkyl]-amino-C(═O)—, mercapto, (C1-C4)alkyl-S—and (C1-C4)alkoxy-(C═O)—.