US 6,649,626 B1 · N-substituted 1-(lactone) isoquinolones for treating nervous disorders

Abstract

The invention concerns compounds of general formula (I) wherein: Z represents a sulphur or oxygen atom, NH, N-alkyl or Nboc; group R′, identical or different, represent each a hydrogen atom, a OCH3 group or a OCH2O group; group R″ represents a hydrogen or a CH3 group; group X represents a carbonyl, sulphonyl or CO2 group; and group R represents an alkyl, aryl, alkenyl or aralkyl group. The invention also concerns the preparation of said compounds, pharmaceutical compositions containing them and their use for stimulating γ-amino-butyric acid activity and as medicine for treating nervous disorders.

Claims11

Dependent claims

A compound represented by the following general formula:

in which:
Z represents a sulfur atom, an oxygen atom, NH, N-alkyl or Nboc,
the groups R′, which may be identical or different from one another, each represent a hydrogen atom, an OCH3 group or an OCH2O group,
the group R″ represents a hydrogen or a CH3 group,
the group X represents a carbonyl, sulfonyl or CO2 group
and the group R represents an alkyl, aryl, alkenyl or aralkyl group in the form of their racemic mixture or of their optically pure isomers.

3 more elements

Dependencies are inferred from the claim text.

N-substituted 1-(lactone) isoquinolones for treating nervous disorders

Life of this patent

N-substituted 1-(lactone) isoquinolones for treating nervous disorders

Life of this patent

Abstract

Claims11